GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs477692 | 1 | rs548390 | chr10:131417427 | MGMT | chr10:131265454-131565783:+ | 0.32 | 4.55 | 1.59E-5 | Response to temozolomide |
| THYM | cis | rs477692 | 1 | rs553371 | chr10:131413676 | MGMT | chr10:131265454-131565783:+ | 0.32 | 4.55 | 1.59E-5 | Response to temozolomide |
| THYM | cis | rs477692 | 1 | rs554792 | chr10:131423181 | MGMT | chr10:131265454-131565783:+ | 0.32 | 4.55 | 1.59E-5 | Response to temozolomide |
| THYM | cis | rs55645543 | 1 | rs55645543 | chr4:122607178 | ANXA5 | chr4:122589153-122618147:- | -0.74 | -4.93 | 3.49E-6 | Age at smoking initiation in chronic obstructive pulmonary disease |
| THYM | cis | rs73726531 | 1 | rs55749163 | chr6:18104645 | NHLRC1 | chr6:18120718-18122851:- | -1.06 | -4.38 | 3.09E-5 | Thiopurine S-methyltransferase activity |
| THYM | cis | rs60843830 | 1 | rs55753056 | chr2:243929 | SH3YL1 | chr2:218138-264810:- | -0.32 | -4.67 | 9.89E-6 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs4802666 | 1 | rs55762838 | chr19:50727179 | NAPSB | chr19:50837059-50848005:- | -0.32 | -4.59 | 1.37E-5 | Disc degeneration (lumbar) |
| THYM | cis | rs55879323 | 1 | rs55879323 | chr1:152168740 | HRNR | chr1:152184558-152196669:- | 0.55 | 5.95 | 4.53E-8 | Inflammatory skin disease |
| THYM | cis | rs2243480 | 1 | rs55895244 | chr7:65387678 | CCT6P1 | chr7:65216092-65228661:+ | 0.66 | 4.82 | 5.38E-6 | Diabetic kidney disease |
| THYM | cis | rs10935120 | 1 | rs55913793 | chr3:134285968 | ANAPC13 | chr3:134196547-134204865:- | 0.58 | 8.01 | 2.88E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs55913793 | chr3:134285968 | CEP63 | chr3:134204575-134293852:+ | 0.41 | 6.04 | 2.93E-8 | Height |
| THYM | cis | rs60843830 | 1 | rs55936726 | chr2:258210 | SH3YL1 | chr2:218138-264810:- | -0.33 | -4.86 | 4.59E-6 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs60843830 | 1 | rs55946380 | chr2:268293 | SH3YL1 | chr2:218138-264810:- | -0.33 | -4.86 | 4.59E-6 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs9902453 | 1 | rs55971458 | chr17:28427016 | EFCAB5 | chr17:28256874-28435469:+ | 0.31 | 4.23 | 5.4E-5 | Coffee consumption (cups per day) |
| THYM | cis | rs12780845 | 1 | rs56015036 | chr10:17226767 | CUBN | chr10:16865966-17171816:- | 0.31 | 4.8 | 5.85E-6 | Homocysteine levels |